Ex Parte LEE - Page 14


                  Appeal No. 2003-0528                                                           Page 14                   
                  Application No. 09/314,841                                                                               
                  phospholipid vesicles to remove detergents wherein the vesicles are dialyzed                             
                  against two changes of buffer in order to trap different salts in the vesicles….”                        
                         As discussed, supra, the examiner has not provided the evidence                                   
                  necessary to demonstrate that the Brucato, Butler, or Brown prothrombin                                  
                  reagents could be modified in a manner that would retain shelf life as disclosed                         
                  by Butler.  In our opinion, Mimms fails to make up for the deficiency in Brucato,                        
                  Butler, Brown, Schwinn and Prestrelski.  Therefore, we reverse the rejection of                          
                  claim 30 under 35 U.S.C. § 103 as being unpatentable over Brown in view of                               
                  Brucato, Butler, Schwinn, Prestrelski and Mimms.                                                         

                                                      REVERSED                                                             


                                                                           )                                               
                                       Sherman D. Winters                  )                                               
                                       Administrative Patent Judge         )                                               
                                                                           )                                               
                                                                           )                                               
                                                                           ) BOARD OF PATENT                               
                                       Donald E. Adams                     )                                               
                                       Administrative Patent Judge         )   APPEALS AND                                 
                                                                           )                                               
                                                                           ) INTERFERENCES                                 
                                                                           )                                               
                                       Lora M. Green                      )                                               
                                       Administrative Patent Judge         )                                               














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