Ex Parte DE LA METTRIE et al - Page 10




          Appeal No. 2003-0615                                                        
          Application No. 09/319,165                                                  


          (col. 2, line 50 - col. 3, line 2).  In Tsujino’s examples 5                
          and 7 the appellants’ first, second, fourth and fifth components            
          are used in combination.  Tsujino does not use the appellants’              
          coupler in any of the examples.                                             
               For the reasons given above regarding Yamahatsu, the                   
          appellants’ claimed invention would have been prima facie obvious           
          to one of ordinary skill in the art over Tsujino.                           
               Moreover, Tsujino teaches that when hydrogen peroxide is               
          used as an oxidizing agent in a hair dye composition, “damage of            
          hair to some degree is inevitable and also skin trouble might be            
          caused depending on the user” (col. 3, lines 19-21).  Tsujino               
          also teaches that “[a]ccording to the present invention, a good             
          finish of hair can be obtained while retaining almost the same              
          dyeing effect as that by using hydrogen peroxide as the oxidizing           
          agent” (col. 5, lines 43-46).  These teachings would have fairly            
          suggested, to one of ordinary skill in the art, substitution of             
          Tsujino’s enzyme/donor for Andrillon’s hydrogen peroxide to                 
          provide good hair finish and to reduce the likelihood of hair and           







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