Appeal No. 2003-0847 Page 2
Application No. 08/744,685
Fell et al. (Fell A) 5,204,244 Apr. 20, 1993
Reff et al. (Reff) 5,998,144 Dec. 07, 1999
Fell et al. (Fell B) “Homologous Recombination in Hybridoma Cells: Heavy Chain
Chimeric Antibody Produced by Gene Targeting,” Proc. Natl. Acad, Sci, USA
Vol. 86, pp. 8507-8511 (1989)
Delente, “Glycosylation Revisited,” Trends in Biotechnolgy, Vol. 3, No. 9 (1985)
Yamawaki-Kataoka et al. (Yamawaki-Kataoka), “The Complete Nucleotide
Sequence of Mouse Immunoglobulin γ2a Gene and Evolution of Heavy Chain
Genes: Further Evidence for Intervening Sequence-Mediated Domain Transfer,”
Nucleic Acids Research Vol. 9, pp. 1365-1381 (1981)
Morrison “Transfer and Expression of Immunoglobulin Genes,”
Ann. Rev. Immunol, Vol. 2 pp. 239-256, (1984)
Paul, “Regulation of Immunoglobin Gene Expression,” Fundamental
Immunology, 3rd ed., Raven Press, Ltd, pp. 351-370 (1993)
Sambrook et al. (Sambrook), Molecular Cloning, A Laboratory Manual, 2nd
Edition, pp. 16.8-16.15 Cold Spring Harbor Laboratory Press, (1989)
Claims 19, 23 and 27 stand rejected under 35 U.S.C. § 112, first
paragraph, as containing subject matter that was not described in the
specification in such a way as to reasonably convey to one skilled in the relevant
art that the inventors, at the time of filing, had possession of the claimed
invention. Claims 6, 15-17, 19, 21-27 and 29-35 stand rejected under 35 U.S.C.
§ 112, first paragraph, as the disclosure as filed fails to enable one skilled in the
art to make and/or use the full scope of the claimed invention. Claims 6, 15-17,
19, 21-27 and 29-35 stand rejected under 35 U.S.C. § 112, second paragraph,
as being indefinite for failing to particularly point out and distinctly claim the
subject matter that appellant regards as the invention. Finally, claims 6, 15-17,
19, 22, 23, 27 and 30 stand rejected under 35 U.S.C. § 103 as being rendered
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