NICHOLS et al. V. TABAKOFF et al. - Page 36





          Interference No. 104,522 Paper`108                                                        
          Nichols v. Tabakoff Page 36                                                               

          considered synthesis of 4-urea kynurenic acid derivatives within or beyond ordinary skill 

          in the art. 13 Nichols did not offer any independent testimony by one of ordinary skill in

          the art sharing Dr. Nichols'opinion that undue or extensive research was required to      

          synthesize 4-urea kynurenate derivatives. Nichols has not pointed to, and we do not       

          find, evidence that Dr. Nichols had to undertake extensive literature searches, scientific

          consultations, etc. as to possible synthesis routes.                                      

          74. To the contrary, Dr. Nichols admitted that Dr. Snell sent him papers on               

          synthesizing similar types of prior art compounds (NR, p. 72,1. 23 - p. 73,1. 22).        

          75. Moreover, according to James A. Ruth, a Ph.D. in synthetic organic chemistry          

          who testified on behalf of Tabakoff, an ordinary organic chemist would have known how     

          to synthesize a 4-urea kynurenic acid, e.g.,                                              
























                13 The Declaration of Dr. K. Lemone Yielding (Ex 2001; NR, pp. 1-2) is confined to authenticating
          six letters (Exs 2003-2007) he received from Dr. Tabakoff.                                








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