Proliferating cells are non-quiescent cells and are in cell cycle stage M, G1,
S or G2.
Slice Application 08/781,752, Paper 15, p. 6.
F 70. M, G1, S or G2 are the four parts of the standard eucaryotic cell growth and division cycle.
M represents the mitotic phase where nuclear division occurs and the cell divides. The G,
phase is the growth phase between the M phase and the beginning of the S phase, In the S
or synthesis phase, the cell's DNA is replicated. The G2 phase is the growth phase between
the end of S phase and the M phase.'
F 71. The examiner's understanding is consistent with the ordinary meaning of "proliferating
cells."
F 72. In short, a proliferating cell is a cell which is actively growing and dividing.
F 73. A cell that is expanded in culture is a cell which has been grown and has multiplied
(undergone cell division) in vitro.
F 74. The ordinary meaning of "somatic cell" is any body cell other than a germ cell or germ cell
precursor, i.e., a cell which will develop through differentiation into a germ cell.'
F 75. Germ cells are also called gametes or sex cells. They are the sperm and ovum.'
F 76. In its ordinary meaning a somatic cell is a differentiated cell.
F 77, Since a totipotent cell may develop through differentiation into any cell, including a germ
cell, a totipotent cell is a germ cell precursor and is not a somatic cell. Put another way, in
its ordinary meaning, a totipotent cell is a non-differentiated cell, and hence is not a somatic
cell.
F 78. According to Stice's written description, an important aspect of the process claimed in Stice
577 is the use of differentiated cells as the donor material in cloning.
6 Alperts et al.,Me Molecular Biology of the Cell 3' Ed. Garland Pub., Inc., N.Y. & London, 1994,
pp. 864-66.
7 Alpens et al., Molecular Biology of the Cell Garland Publishing Co., N.Y. & London, 1994, pp. 10 12
and G-2 1; King et al., A Dictionary of Genetics, Oxford University Press, N.Y., 1997, p. 318. Contra Joint Glossary,
Paper 20, p. 8.
Stedman's Medical Dictionary, 27' Ed., Lippincott Williams & Wilkins, 2000.
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