Ex Parte Llorin et al. - Page 10


               Appeal No.  2002-0780                                        Page      10                 
               Application No.  09/128,340                                                                  
               explanation as to why a person of ordinary skill in the art would have modified the          
               sonication methods taught by the prior art to include a buffer or detergent.                 
                      Upon return of the application, the examiner should take a step back and              
               reevaluate the prior art relied upon.  If the examiner finds that the rejection              
               should be made, the examiner should issue an appropriate Office action setting               
               forth such a rejection, using the proper legal standards and clearly explaining the          
               facts relied upon in support of such a rejection.                                            
               4.  Does Robson teach Mycobacteria tuberculosis is heat resistant?                           
                      According to the examiner (Answer, page 7), Mycobacteria tuberculosis “is             
               taught by Robson to be heat resistant (cols. 1-2, all lines).”  It appears that the          
               examiner has misapprehended the Robson reference.  Contrary to the                           
               examiner’s statement Robson discloses (column 2, lines 13-22) (emphasis                      
               added):                                                                                      
                      The heating of Mycobacteria for lysis is advantageous over known                      
                      methods for lysis of Mycobacteria which involve the use of caustic                    
                      chemicals, time consuming culturing, and mechanical methods                           
                      which use the French press, the Hughes press, sonicating probes,                      
                      bath sonicators, freeze-thawing, glass beads, the Ribi pressure cell,                 
                      and the like (see Table 1).                                                           
                      Upon return of the application, the examiner should take a step back and              
               reevaluate the prior art relied upon, paying careful attention to exactly what the           
               reference teaches.  If the examiner finds that the rejection should be made, the             
               examiner should issue an appropriate Office action setting forth such a rejection,           
               using the proper legal standards and clearly explaining the facts relied upon in             
               support of such a rejection.                                                                 







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