Ex Parte DYKSTRA et al - Page 4


                 Appeal No. 2001-1051                                                         Page 4                    
                 Application No.  08/185,079                                                                            

                 Appeal Brief, page 5 (emphasis in original).  Appellants conclude that                                 
                 Vonderfecht does not motivate the ordinary artisan to use the presently claimed                        
                 compounds for combating a retroviral infection, such as an HIV infection.  We                          
                 agree.                                                                                                 
                        The burden is on the examiner to make a prima facie case of                                     
                 obviousness, and the examiner may meet this burden by demonstrating that the                           
                 prior art would lead the ordinary artisan to combine the relevant teachings of the                     
                 references to arrive at the claimed invention.  See In re Fine, 837 F.2d 1071,                         
                 1074, 5 USPQ2d 1596, 1598-99 (Fed. Cir. 1988).  Obviousness is determined in                           
                 view of the sum of all of the relevant teachings in the art, not isolated teachings                    
                 in the art.  See In re Kuderna, 426 F.2d 385, 389, 165 USPQ 575, 578                                   
                 (CCPA 1970); see also In re Shuman, 361 F.2d 1008, 1012, 150 USPQ 54,                                  
                 57 (CCPA 1966).  In assessing the teachings of the prior art references, the                           
                 examiner should also consider those disclosures that may teach away from the                           
                 invention.  See In re Geisler, 116 F.3d 1465, 1469, 43 USPQ2d 1362, 1365                               
                 (Fed. Cir. 1997).                                                                                      
                        In this case, each of the Tidwell references teaches that “[t]he suppressive                    
                 effect [of the compound taught by Tidwell] is virus specific, however, and does                        
                 not extend to cell fusion induced by P-3 virus or the MP mutant of herpes                              
                 simplex type I.”  Tidwell I, Col. 2, ll. 64-67; Tidwell II, Cols. 2-3, ll. 66-1; Tidwell III,          
                 Col. 3, ll. 1-4.  Thus, Tidwell expressly teaches away from using the compounds                        
                 on viruses other than RSV.  The examiner relies on Col. 11, lines 43-45, of                            
                 Tidwell III, finding that the teaching at Col. 11 renders the above teaching moot.                     





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