The opinion in support of the decision being entered today was not written
for publication and is not binding precedent of the Board.
Paper No. 27
UNITED STATES PATENT AND TRADEMARK OFFICE
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BEFORE THE BOARD OF PATENT APPEALS
AND INTERFERENCES
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Ex parte ELDON E. BAIRD and PETER B. DERVAN
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Appeal No. 2003-0395
Application No. 09/374,704
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ON BRIEF
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Before WILLIAM F. SMITH, SCHEINER and GRIMES, Administrative Patent Judges.
SCHEINER, Administrative Patent Judge.
DECISION ON APPEAL
This is a decision on appeal under 35 U.S.C. § 134 from the final rejection of
claims 1, 3-19, 25 and 26. Claims 20-24, also pending, have been allowed.
Claims 1 and 8 are representative of the subject matter on appeal:
1. A polyamide molecule that specifically binds to base pairs in the minor groove
of a DNA molecule, said polyamide molecule comprising:
one or more amino acids comprising a moiety selected from the group consisting
of N-methylpyrrole, 3-hydroxy-N-methylpyrrole, and N-methylimidazole, wherein one or
more of said amino acid(s) are not "-amino acids; and
a positive patch consisting of a rigid group adjacent to a positively charged
group, said rigid group comprising a first and a second amino acid; said first amino acid
being selected from the group consisting of arginine, proline, lysine, and hydroxyproline;
said second amino acid being selected from the group consisting of proline, glycine,
serine, threonine, leucine, isoleucine, valine, alanine, and hydroxyproline.
8. The polyamide of claim 1 wherein the positive patch comprises the amino acid
sequence Arg-Pro-Arg.
The references relied on by the examiner are:
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