Ex Parte WAGNER et al - Page 4


                 Appeal No.  2003-1126                                                       Page 4                   
                 Application No.  08/444,285                                                                          

                 the full scope of the claimed subject matter.  After careful review of the record                    
                 and consideration of the issues before us, we affirm the obviousness-type double                     
                 patenting rejection, but reverse the rejection under 35 U.S.C. § 112, first                          
                 paragraph.                                                                                           
                                                   DISCUSSION                                                         
                 1.     Rejection for Obviousness-type Double Patenting                                               
                        Claims 39, 41, 43, 45, 50, 51, 55-79, 82, 83, 86-114, 116 and 119 stand                       
                 rejected under the judicially created doctrine of obviousness-type double                            
                 patenting as being unpatentable over claims 1-17 of U.S. Patent No. 4,873,191.                       
                        According to the rejection, “the nonhuman transgenic mammal and                               
                 methods of producing a polypeptide or protein using the mammal of claims 39,                         
                 41, 43, 45, 50, 51, 55-79, 82, 83, 86-114, 116 and 119 are obvious over claims 1-                    
                 7 of the ’191 as the mammal of the claims is made by the method of [sic] claimed                     
                 in ’191.”  Examiner’s Answer, page 3.                                                                
                        Appellants state that they intend to file a terminal disclaimer upon the                      
                 indication of allowable subject matter.  As appellants do not argue the rejection                    
                 and as a terminal disclaimer has not been filed, this rejection is affirmed.                         
                 2.     Rejection under 35 U.S.C. § 112, first paragraph                                              
                        Claims 39, 41, 43, 45, 50, 51, 55-79, 82, 86-114, 116 and 119 stand                           
                 rejected under 35 U.S.C. § 112, first paragraph.  According to the rejection,                        
                        the specification, while being enabling for a transgenic mouse                                
                        whose somatic and germ cells contain a DNA sequence encoding a                                
                        protein of interest under the control of a transcriptional control                            
                        sequence and methods of using the mouse to produce the protein                                
                        in its blood and isolating the protein from the blood, does not                               





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