Ex Parte ROTH et al - Page 2


                 Appeal No.  2003-1167                                                          Page 2                  
                 Application No.  09/195,340                                                                            
                                                                                                                       
                               b) mixing a biologically active molecule with the material, wherein                      
                                   the biologically active molecule is effective to promote                             
                                   vascularization or revascularization of the tissue,                                  
                               c) applying the material to the site where treatment is needed, and                      
                               d) covalently polymerizing the material to permit controlled release                     
                                   of a therapeutically effective amount of the biologically active                     
                                   molecule.                                                                            
                        The references relied upon by the examiner are:                                                 
                 Hunziker                          5,206,023                   Apr. 27, 1993                          
                 Sierra et al. (Sierra)             5,290,552                   Mar. 1, 1994                           
                 Marx                              5,607,694                   Mar. 4, 1997                           
                 Hubbell et al. (Hubbell)           5,626,863                   May 6, 1997                            
                                             GROUNDS OF REJECTION                                                       
                        Claims 6, 14, 18, 19 and 24 stand rejected under 35 U.S.C. § 102(e) as                          
                 being anticipated by Hubbell.                                                                          
                        Claims 6, 14, 15, 18, 19, 21-24, 26 and 27 stand rejected under 35 U.S.C.                       
                 § 103 as being unpatentable over Hubbell alone, or in combination with Sierra,                         
                 Hunziker and Marx individually, or in combination.                                                     
                        We reverse.                                                                                     
                                                    DISCUSSION                                                          
                 THE REJECTION UNDER 35 U.S.C. § 102:                                                                   
                        The examiner finds (Answer, bridging paragraph, pages 3-4), “Hubbell                            
                 discloses a method of applying a composition containing monomers at the                                
                 needed site and photo polymerizing the monomers to form a [sic] covalently                             
                 linked polymers.  The composition contains a biologically active material such as                      
                 proteins, enzymes and nucleotides.  The composition also contains micro                                
                 spheres carrying the active agent….”  While the examiner appreciates (Answer,                          







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