Appeal No. 2003-1469 Page 10 Application No. 08/479,886 in which the experimentation should proceed” (quoting Ex parte Jackson, 217 USPQ 804, 807 (1982)). Other Issues This appeal is being decided concurrently with appeal 2003-1668 (application serial no. 08/479,883). According to Appellants, both applications are divisionals of application 08/122,548. Claims 66 and 67 of the instant application read as follows: 66. A variant of a wild type growth hormone comprising: (a) a first mutation in an amino acid sequence of a first receptor binding site selected from the group consisting of: (i) amino acid residue L15, R16, R19 and Q22; (ii) amino acids 46-71; and (iii) amino acids 169-184, and (b) a second mutation in an amino acid sequence of a second receptor binding site selected from the group consisting of: (i) amino acids 1-15; and (ii) amino acids 106-128. 67. The variant of claim 66 wherein said variant is covalently attached to a polyethylene glycol molecule. Claims 54 and 74 of the ‘883 application read as follows: 54. A variant of a native mature mammalian growth hormone comprising, said variant having a non-naturally occurring amino acid sequence or a covalent modification, comprising: (a) a first mutation in a first region selected from the group consisting of (i) amino acid residue L15, R16, R19 and Q22, (ii) the C-terminal 2/3 of the loop linking helices 1 and 2, and (iii) the C-terminal 1/2 of helix 4; and (b) a second mutation in a second region selected from the group consisting of (i) a region corresponding to residue 1 to residue 15 of mammalian growth hormone and (ii) a region corresponding to residue 106 to residue 128 of mammalian growth hormone, numbered from the N-terminus.Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 NextLast modified: November 3, 2007