Ex Parte Donoho et al - Page 4


                 Appeal No. 2003-1794                                                         Page 4                   
                 Application No. 09/804,969                                                                            

                        additionally be used as a method for the inhibition of abnormal NHP                            
                        activity.  Thus, such antibodies may, therefore, be utilized as part of                        
                        treatment methods.                                                                             
                 Page 23.                                                                                              
                                                     Discussion                                                        
                        The claims are directed to a nucleic acid molecule comprising the                              
                 sequence shown in the specification’s SEQ ID NO:14 (claim 8), and other nucleic                       
                 acid sequences that encode the same amino acid sequence (claim 10).  The                              
                 examiner rejected the claims as lacking patentable utility.1                                          
                 1.  Claim construction                                                                                
                        We interpret claims 8 and 10 to require the entire, specific amino acid or                     
                 nucleotide sequence that is recited.  Thus, claim 8 requires the entire sequence                      
                 of nucleotides shown in SEQ ID NO:14 without substitutions, insertions, or                            
                 deletions (although the open claim language permits additional sequences before                       
                 and/or after the recited sequence).  Likewise, claim 10 requires nucleotides                          
                 encoding at least the entire, unaltered amino acid sequence of SEQ ID NO:15.                          
                        This interpretation of the claims is supported by their literal terms as well                  
                 as by the prosecution history.  As originally filed, the claims encompassed                           
                 fragments of SEQ ID NO:14 (original claim 8) as well as polynucleotides that,                         
                 among other things, hybridize to SEQ ID NO:14 under stringent conditions (claim                       
                 9).  These claims were rejected as anticipated.  See Paper No. 8, mailed Dec.                         

                                                                                                                       
                 1 The examiner rejected the claims under both 35 U.S.C. § 101 and 35 U.S.C. § 112, first              
                 paragraph.  The rejection for nonenablement, however, was presented simply as a corollary of          
                 the finding of lack of utility.  See the Examiner’s Answer, page 6.  Therefore, although we discuss   
                 only the § 101 rejection, our conclusion also applies to the § 112 rejection.                         





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