Appeal No. 2004-0275
Application No. 09/09/318,186
Claim 60 is illustrative of the claims on appeal and reads as follows:
60. A method for screening chiral selectors from a parallel library
comprising:
(a) forming a parallel library by individually synthesizing chiral selectors
onto a polymeric synthesis resin;
(b) incubating each individual chiral selector, attached on the polymeric
resin, with an analyte having a mixture of a R-enantiomer and a S-enantiomer:
(c) analyzing the resultant of step (b) to identify which chiral selector
selectively adsorbed one of the R-enantiomer and the S-enantiomer;
(d) attaching the identified chiral selector onto a support; and
(e) resolving the analyte of step (b) into the R-enantiomer and the S-
enantiomer with the attached chiral selector on the support.
The references relied upon by the examiner are:
Lam et al. (Lam) 5,858,670 Jan. 12, 1999
Welch, et al. (Welch), “Microscale Synthesis and Screening of Chiral Stationary
Phases,” Enantiomer, Vol. 3, pp. 471-476 (1998).
Liu, et al. (Liu), “Polymer- versus Silica-Based Separation Media: Elimination of
Nonspecific Interactions in the Chiral Recognition Process through Functional
Polymer Design,” Anal. Chem., Vol. 69, pp. 61-65 (1997).
Weingarten, et al. (Weingarten), “Enantioselective Resolving Resins from a
Combinatorial Library. Kinetic Resolution of Cyclic Amino Acid Derivatives,” J.
Am. Chem. Soc., Vol. 120, pp. 9112-9113 (1988).
Pirkle, et al. (Pirkle), “A Chiral Stationary Phase Which Affords Unusually High
Levels of Enantioselectivity,” Chirality, Vol. 3, pp. 183-187 (1991).
Grounds of Rejection
Claims 60-65, 67, 69, 71, 74 and 80 stand rejected under 35 U.S.C. §
103(a) for obviousness over Welch in view of Liu and further in view of
Weingarten.
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