Appeal No. 2004-1734
Application No. 08/942,369
Claims 20, 26, 38 and 43 are representative of the subject matter on appeal and
read as follows:
20. A method of detecting the presence of urinary pathogens in a
biological sample and of simultaneously determining the susceptibility of the
urinary pathogens to antimicrobial agents, said method comprising:
providing a multicompartment assay device comprising:
at least one compartment comprising a medium capable of sustaining
growth of total microbial organisms; at least one compartment comprising a
uropathogenic specific medium; and, at least one compartment comprising an
antimicrobial susceptibility interpretation medium;
placing a portion of the biological sample respectively in said at least one
compartment comprising a medium capable of sustaining growth of total
microbial organisms; said at least one compartment comprising a uropathogenic
specific medium; and, said at least one compartment comprising an antimicrobial
susceptibility interpretation medium comprising an antimicrobial agent;
whereby metabolism of a signal generating substrate and production of a
detectable signal in said at least one compartment comprising a medium capable
of sustaining growth of total microbial organisms indicates the presence of
microbial organisms in a sample; metabolism of a signal generating substrate
and production of a detectable signal in said at least one compartment
comprising a uropathogenic specific medium indicates the presence of urinary
pathogens in the sample; and metabolism of a signal generating substrate and
production of a detectable signal in said at least one compartment comprising an
antimicrobial susceptibility interpretation medium indicates that the organisms
lack susceptibility to the antimicrobial agent comprised in said antimicrobial
susceptibility interpretation medium; and
examining the compartments to determine the presence of urinary
pathogens in said biological sample and the susceptibility of said urinary
pathogens to said antimicrobial agents.
26. The method of claim 20 wherein the at least one antimicrobial
susceptibility interpretation medium comprises amoxicillin, clavulanic
acid/amoxicillin, or enrofloxacin.
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