Ex Parte CHEN et al - Page 9




              Appeal No. 2004-1734                                                                                       
              Application No. 08/942,369                                                                                 
                     Brocco discloses an antibiotic assay for urinary pathogens which comprises                          
              seventeen (17) dried antibiotics, which include  inter alia, amoxicillin and clavulanic acid,              
              in various wells of a microtiter device.  Brocco, pp. 4 and 10.                                            
              Rejection I                                                                                                
                     The examiner argues that it would have been obvious to one of ordinary skill in                     
              the art                                                                                                    
                     to include the nonselective medium of Libman in the method of Johnson where                         
                     the motivation would have been to provide a positive control for the microbial                      
                     growth, as suggested by Johnson.  It would also have been obvious to use the                        
                     selective medium of Thaller as the selective medium in the method of Johnson                        
                     where the motivation would have been to “analyze very selectively” for organisms                    
                     causing an infection (Johnson, col. 3, lines 31-35) in order to presumptively                       
                     identify the causative organism in order to determine an appropriate course of                      
                     treatment, as suggested by both Libman (col. 2, lines 48-53) and Johnson (col. 3,                   
                     lines 30-39).  One would also have been motivated to use the selective medium                       
                     of Thaller in the method of Johnson and Libman because it is an improvement                         
                     over other selective medium such as that taught by Libman.  [Answer, pp. 5-6].                      
                     It is well established that the examiner has the initial burden under 35 U.S.C. §                   
              103 to establish a prima facie case.  In re Oetiker, 977 F.2d 1443, 1445, 24 USPQ2d                        
              1443, 1444 (Fed. Cir. 1992); In re Piasecki, 745 F.2d 1468, 1471-72, 223 USPQ 785,                         
              787-88 (Fed. Cir. 1984).  To that end, it is the examiner’s responsibility to show that                    
              some objective teaching or suggestion in the applied prior art, or knowledge generally                     
              available in the art, would have led one of ordinary skill in the art to combine the                       
              references to arrive at the claimed invention.  Pro-Mold & Tool Co. v. Great Lakes                         
              Plastics, Inc., 745 F.3d 1568, 1573, 37 USPQ2d 1626, 1629 (Fed. Cir. 1996).                                
                     We commend the examiner for his thoroughness in briefing this case, but even                        

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