Ex Parte Esser et al - Page 4




                     Appeal No. 2005-0393                                                                                                                                               
                     Application 09/536,728                                                                                                                                             
                                Having carefully considered the record before us which includes the appellants’                                                                         
                     Brief and Reply Brief, as well as the examiner’s Answer, we (i) reverse Rejection I;                                                                               
                     (ii) affirm Rejection II, but denominate the affirmance as a new ground of rejection; and                                                                          
                     (iii) remand Rejection III and IV for further consideration by the examiner.                                                                                       
                                We point out that given our disposition of this case, claim 26 is now free of the                                                                       
                     prior art.                                                                                                                                                         


                                                                     Background and Discussion                                                                                          
                                As indicated by the claims above, the present invention is directed to substituted                                                                      
                     phenyliminoimidazolines and pharmaceutical compositions which comprise them.  Said                                                                                 
                     phenyliminoimidazolines are said to be useful as “"1L-agonists for treating urinary                                                                                
                     incontinence, particularly, stress incontinence.”  Specification, p. 1, para. 1.                                                                                   
                                As discussed above, the claims stand or fall with representative claims 21                                                                              
                     and 39.                                                                                                                                                            
                                                                                          I.                                                                                            
                                The examiner argues that Olson discloses 2-(substituted phenylimino)                                                                                    
                     imidazolidines which are structurally similar to the claimed compounds when R1 is                                                                                  
                     methyl, R2 is NR6R7, R6 is methyl, n-propyl or isopropyl, R7 is hydrogen, methyl, ethyl, n-                                                                        
                     propyl or isopropyl, and R3, R4 and R5 are hydrogen.  Answer, pp. 3-4.  According to the                                                                           
                     examiner, the prior art compound differs from the claimed compound in that the group                                                                               



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