Ex Parte Sofia Totterman et al - Page 3




              Appeal No. 2005-2414                                                                       3               
              Application No. 10/241,763                                                                                 


                                                        OPINION                                                          
                     For all of the reasons expressed by the examiner, and for the additional reasons set                
              forth infra, we will sustain all of the rejections of record.                                              
                     With respect to claim 1, the appellants take issue with the examiner’s selection of                 
              breast volume as a biomarker and the selection of the quantification of the tumor surface                  
              as a derivation of a quantitative measurement of the biomarker (brief, pages 5 and 6).                     
              According to the appellants (brief, page 5), the examiner’s “statements are mutually                       
              exclusive and cannot both be true.”  Notwithstanding the examiner’s mixing of volume and                   
              surface, we find that the examiner’s finding of facts (answer, pages 3 and 4) also points                  
              out tumor extent/shape in Gilhuijs (column 1, lines 14 through 16) as a biomarker.  Gilhuijs               
              derives “at least one quantitative measurement of the at least one biomarker” by                           
              “quantification of the tumor surface” (column 6, lines 61 through 64).  We additionally find               
              that the “radius” is also a quantitative measurement of the extent/shape tumor biomarker                   
              and is also a quantitative measurement of the malignant lesion with a necrotic core                        
              biomarker1 (column 6, lines 19 through 36).  Thus, the anticipation rejection of claim 1 is                
              sustained.                                                                                                 






                     1 The biomarkers in Gilhuijs are found in the list of biomarkers of claim 10, and the quantitative  
              measure in Gilhuijs is found in the list set forth in claim 11.                                            







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