Ex Parte Polonsky et al - Page 3


                Appeal No.  2005-0258                                                       Page 3                 
                Application No.  09/768,877                                                                        
                       II. Claims 19, 49 and 53 stand rejected under 35 U.S.C. § 112, first                        
                                paragraph, as the specification fails to adequately describe the                   
                                claimed invention.                                                                 
                       III. Claims 18-21, 49-51, 53-64, 115 and 116 stand rejected under                           
                                35 U.S.C. § 112, first paragraph, as the specification fails to                    
                                adequately describe the claimed invention.                                         
                       IV. Claims 18-21, 49-51, 53-64, 115 and 116 stand rejected under                            
                                35 U.S.C. § 112, first paragraph, as based on an insufficient                      
                                disclosure to support or enable the scope of the claimed                           
                                invention.                                                                         
                We direct attention to the second and third ground of rejection.  The second                       
                ground of rejection is a rejection of claims 19, 492 and 53 under the written                      
                description provision of 35 U.S.C. § 112, first paragraph.  At page 6 of the                       
                Answer, the examiner refers to this rejection as “a new matter rejection.”  See                    
                also, Decision page 4, wherein the rejection is discussed under the heading “New                   
                Matter.”  According to the examiner (Answer, page 7), “there is no indication that                 
                methods using specifically calpain 10 polypeptides which comprise amino acids                      
                1-47 of SEQ ID NO: 2 were within the scope of the invention as conceived by                        
                [a]ppellants at the time the application was filed.”  See also, Decision, page 4.                  
                Throughout the statement of this rejection the examiner focuses on “amino acids                    
                1-47 of SEQ ID NO: 2.”  Appellants’ statement of the issues, as it appears on                      
                pages 4 and 5 of the Brief, recognizes the examiner’s                                              
                focus on the phrase “amino acids 1-47 of SEQ ID NO: 2.”  In this regard, we note                   



                                                                                                                   
                2 According to the examiner (Answer, page 6), claims 19 and 53 “encompass a method of              
                screening for a modulator of calpain 10 function wherein the calpain 10 polypeptide used           
                comprises amino acids 1-47 of SEQ ID NO:2.”  As we understand it, claim 49 is included in this     
                rejection due to its dependency on claim 19.  See id.                                              





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