Ex Parte Polonsky et al - Page 4


                Appeal No.  2005-0258                                                       Page 4                 
                Application No.  09/768,877                                                                        
                that appellants’ specifically characterize this issue as whether “claims 19 and 53                 
                lack written description under 35 U.S.C. [§] 112, first paragraph for the phrase                   
                ‘amino acids 1-47 of SEQ ID NO: 2?’”  Brief, pages 4 and 5.  Appellants do not                     
                dispute our decision on the merits of this ground of rejection.                                    
                       Appellants’ Request is directed to our decision on the merits of the third                  
                ground of rejection.  The third ground of rejection is a rejection of claims 18-21,                
                49-51, 53-64, 115 and 116 under the written description provision of 35 U.S.C.                     
                § 112, first paragraph, as the specification fails to adequately describe the                      
                claimed invention.  This ground of rejection differs from the second ground of                     
                rejection because it is not based on the concept of “new matter” but instead                       
                focuses on the failure of appellants’ specification to provide written descriptive                 
                support for the genus of calpain 10 polypeptides set forth in claim 51.  See e.g.,                 
                Decision page 8, “the method of claim 51 is open to the use of a calpain 10                        
                polypeptide of any structure from any source.  Therefore, the method of claim 51                   
                reads generically on the use of any calpain 10 polypeptide from any source.”                       
                Appellants’ Request does not dispute this construction of claim 51.  In addition,                  
                we note that appellants’ statement of the issues, as it appears on pages 4 and 5                   
                of the Brief, specifically characterize this issue as whether “claims 18-21, 49-51,                
                and 53-64 lack written description under 35 U.S.C. [§] 112, first paragraph for the                
                phrase ‘calpain 10?’”                                                                              












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