Ex Parte BURTON et al - Page 19


                 Appeal No.  2005-1344                                                         Page 19                   
                 Application No.  08/468,610                                                                             
                 when the aqueous medium has either a high or a low ionic strength.”  See e.g.,                          
                 claim 1.  Assuming that the aqueous media is a whole cell extract, we would                             
                 encourage the examiner to take a step back and determine whether the resins                             
                 disclosed in appellants’ specification would be capable of binding a single “target”                    
                 protein/peptide, from such an aqueous media.  It may be that a number of                                
                 proteins, of which only one is the so-called target protein/peptide, in a cell extract                  
                 may exhibit the same pI.                                                                                
                        Accordingly, we encourage the examiner to take a step back, and review                           
                 the claimed invention in light of the specification to determine whether a person                       
                 of ordinary skill in the art would find it reasonable for a resin to bind a single                      
                 “target” protein from any aqueous media, particularly an aqueous media that                             
                 contains other proteins/peptides of similar size and pI.                                                


                                             VACATED and REMANDED                                                        

                                                                          )                                              
                                       Joan Ellis    )                                                                   
                                       Administrative Patent Judge )                                                     
                                                                          )                                              
                                                                          ) BOARD OF PATENT                              
                                                                          )                                              
                                       Toni R. Scheiner   )      APPEALS AND                                             
                                       Administrative Patent Judge )                                                     
                                                                          )   INTERFERENCES                              
                                                                          )                                              
                                                                          )                                              
                                       Donald E. Adams   )                                                               
                                       Administrative Patent Judge )                                                     









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