Ex Parte B. Santos et al - Page 8


                 Appeal No.  2006-0251                                                           Page 8                   
                 Application No.  10/017,697                                                                              
                 composition cannot anticipate appellants’ taste-masked liquid pharmaceutical                             
                 composition.                                                                                             
                         Accordingly, we reverse the rejection of claims 1-4, 7, 8, 10, 11, 13, 15-19,                    
                 22-24, 26, 28-33 and 43-46 under 35 U.S.C. § 102(b) as anticipated by White.                             

                 Obviousness:                                                                                             
                         Claim 5, 6, 9, 12, 14 and 20 stand rejected under 35 U.S.C. § 103 as                             
                 being unpatentable over White.  Each of claims 5, 6, 9, 12, 14 and 20 depend                             
                 ultimately from and further limit claim 1, to a recited amount of polyethylene                           
                 glycol, polyvinlpyrrolidone, and sweetening agents, as set forth in claims 5, 6, 9,                      
                 12 and 14; or to the inclusion of specific antibiotics, as set forth in claim 20.                        
                 While the examiner recognizes that White does not teach the limitations of claim                         
                 5, 6, 9, 12, 14 and 20, the examiner nevertheless maintains that they would have                         
                 been prima facie obvious to a person of ordinary skill in the art at the time the                        
                 invention was made.  The examiner, however, does not rely on any additional                              
                 evidence to supplement the teachings of White.                                                           
                         As discussed above, White teaches a composition (see e.g., claim 1) that                         
                 differs from the claimed invention only in the inclusion of a tri-ester as an                            
                 essential component of the composition.  In addition, as discussed above, the                            
                 evidence of record establishes that the essential tri-ester is bitter and renders a                      
                 composition comprising a drug, polyethylene glycol and polyvinyl pyrrolidone                             
                 unacceptably bitter.  The examiner provides no evidence, and therefore has not                           
                 established, that it would have been prima facie obvious to a person of ordinary                         
                 skill in the art at the time the invention was made to prepare White’s composition                       






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