Appeal No. 2006-0298 Page 2
Application No. 10/021,955
no longer exists. Cf. Ex parte Zambrano, 58 USPQ2d 1312, 1313 (Bd. Pat. App.
& Int. 2001).
BACKGROUND
Claims 1-7, 35-40 and 42-61 are pending, claims 1, 35, 49 and 57 are
representative of the claims on appeal, and are reproduced below.
1. A method of diagnosing myelinopathy in an individual, said myelinopathy
resulting from a periaxin alteration in the individual, comprising the steps of:
obtaining a sample containing nucleic acid from said individual;
assaying said sample for an alteration in a periaxin polynucleotide,
wherein said assaying step provides said diagnosis.
35. A method of detecting the presence or absence of a mutation associated
with a myelinopathy, said myelinopathy resulting from a periaxin mutation in the
individual, the method comprising:
(a) isolating a test nucleic acid from a subject, said test nucleic acid
comprising a periaxin polynucleotide;
(b) comparing the test nucleic acid to a reference wild-type periaxin
polynucleotide; and
(c) determining the differences between the test nucleic acid and the
reference wild-type periaxin polynucleotide, wherein the differences are
mutations in the periaxin polynucleotide of the subject, and wherein said
detection of the presence or absence of the mutation is therein provided.
49. A method of detecting a polymorphism or mutation in a periaxin
polynucleotide of an individual, comprising the steps of:
obtaining a sample comprising said periaxin polynucleotide from said
individual;
assaying said periaxin polynucleotide for the polymorphism or mutation.
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