Appeal No. 2006-0704 Page 39 Application No. 10/060,697 bone chips in the composition is to fill large voids in bone. See, e.g., Wironen, page 13, lines 11-14. It would appear to be quite rational that one looking at a large void in a bone, would select the appropriate size and quantity of bone chips to fill the void. In my opinion, the prior art did not recite a particular concentration of bone chips because it would appear that a person of ordinary skill in the art would understand that it would depend on the size of the void to be filled. “[T]he test of obviousness is not express suggestion of the claimed invention in any or all of the references but rather what the references taken collectively would suggest to those of ordinary skill in the art presumed to be familiar with them.” In re Rosselet, 347 F.2d 847, 851, 146 USPQ 183, 186 (CCPA 1965). Accordingly, I do not find appellants’ argument persuasive. For the foregoing reasons, I would affirm the rejection of claim 23 under 35 U.S.C. § 103(a) as being unpatentable over the combination of O’Leary, Yim and Wironen. As discussed supra claims 24-30 fall together with claim 23. Majority opinion: Rigidly applying the suggestion test and failing to consider all the evidence of record, the majority concludes (Supra, page 9), “[t]he examiner has not adequately explained how the prior art would have suggested modifying O’Leary’s composition by adding calcium sulfate to it.[ ]42 Nor has the examiner provided a rationale based on the knowledge of those of skill in the art or the nature of the problem to be solved.” 42 While the majority recognizes (supra, bridging sentence, pages 7), “Yim’s compositions have two required components: calcium sulfate hemihydrate-containing substance (CSHS) and an osteogenic protein [(BMP)]”, the majority ignores Yim’s disclosure that in this embodiment “CSHS provides a structural matrix function, an osteoconductive matrix, and a protein sequestering function.” Yim, column 8, lines 25-28. As the subject matter before this panel is directed to a bone graft composition itPage: Previous 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 NextLast modified: November 3, 2007