Ex Parte Lanza et al - Page 7




               Appeal No. 2006-1031                                                                                                    
               Application No. 09/774,278                                                                                              
                       In rejecting claims under 35 U.S.C. §103, the examiner bears the initial burden of                              
               presenting a prima facie case of obviousness.  See In re Rijckaert, 9 F.3d 1531, 1532,                                  
               28 USPQ2d 1955, 1956 (Fed. Cir. 1993).   A prima facie case of obviousness is                                           
               established when the teachings from the prior art itself would appear to have suggested                                 
               the claimed subject matter to a person of ordinary skill in the art.  In re Bell, 991 F.2d                              
               781, 783, 26 USPQ2d 1529, 1531 (Fed. Cir. 1993).  An obviousness analysis requires                                      
               that the prior art both suggest the claimed subject matter and reveal a reasonable                                      
               expectation of success to one reasonably skilled in the art.   In re Vaeck, 947 F.2d 488,                               
               493, 20 USPQ2d 1438, 1442  (Fed. Cir. 1991).  We do not find the examiner has                                           
               established, on the evidence before us, that the microbubbles of θstensen remain in                                     
               liquid form throughout the performance of the imaging steps of the disclosed method, or                                 
               that the microbubbles of θstensen do not contain more than 10% gas at any phase of                                      
               the method in which the liquid microbubbles are used.                                                                   

















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