Ex Parte Cox et al - Page 2


                  Appeal No. 2006-1270                                                           Page 2                    
                  Application No. 10/222,614                                                                               


                  122. The cell of claim 121, wherein the cell is a human cell.                                            
                  123. The cell of claim 122, wherein the cell is a stem cell.                                             
                  124. The cell of claim 123, wherein the cell is a hematopoietic stem cell.                               
                         Claims 123 and 124 stand rejected under 35 U.S.C. § 112, first paragraph,                         
                  as failing to comply with the enablement requirement.  In addition, Claims 114,                          
                  116 and 119-122 stand rejected under 35 U.S.C. § 103(a) as being obvious over                            
                  the combination of Brenneman1 and Chandrasegaran.2  After careful review of                              
                  the record and consideration of the issues before us, we reverse both rejections.                        
                                                     DISCUSSION                                                            
                         Claims 123 and 124 stand rejected under 35 U.S.C. § 112, first paragraph,                         
                  “as failing to comply with the enablement requirement.  The claim(s) contains                            
                  subject matter which was not described in the specification in such a way as to                          
                  enable one skilled in the art to which it pertains, or with which it is most nearly                      
                  connected, to make and/or use the invention.”  Examiner’s Answer, page 3.                                











                                                                                                                           
                  1 Brenneman et al. (Brenneman), “Stimulation of intrachromosomal homologous recombination in             
                  human cells by electroporation with site-specific endonucleases,” PNAS, Vol. 93, pp. 3608-12             
                  (1996).                                                                                                  
                  2 Chandrasegaran, U.S. Pat. No. 5,792,640, issued August 11, 1998.                                       





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