Ex Parte Ilsley et al - Page 21


             Appeal No. 2006-1547                                                             Page 21                
             Application No. 10/114,668                                                                              


                                New Grounds of Rejection under 37 C.F.R. § 41.50                                     
                    New grounds of rejection are set forth below over claims 8-11 and 19-28.  The                    
             common feature of all these claims is the requirement that the array be in a “dry,                      
             storage stable format.”  Although the dry, stable format is a key feature distinguishing                
             dependent claim 8 and independent claim 19 from independent claims 1 and 29, only                       
             several lines (page 31) were devoted to it in the 43-page Answer.  This feature was                     
             ignored until the appeal stage, indicating that proper attention to it had not been given               
             during prosecution.                                                                                     


             Claims 8 and 9                                                                                          
                    Pursuant to 37 C.F.R. § 41.50, a new ground of rejection is made for claims 8                    
             and 9 under 35 U.S.C. § 103 as being obvious over Ulfendahl in view of Yu and                           
             Morozov8.                                                                                               
                    The disclosures of Ulfendahl and Yu have been discussed above and in the                         
             Examiner’s Answer.  Ulfendahl describes arrays comprising DNA primers, polymerases,                     
             and precursor nucleotides, including dATP, dGTP, dTTP, and dCTP at distinct                             
             locations.  See, e.g., Ulfendahl, Example 1, columns 6-8.  At least one of the                          
             nucleotides is labeled (“Fl-dCTP”).  Id., column 7, line 46.  Thus, the primer composition              
             required in claim 8 is met.  Divalent cations (magnesium) and buffering salts (Tris-HCl)                
             are present as required by claim 9.  Id., column 7, lines 60-65.                                        


                                                                                                                     
             8 Morozov et al. (Morozov) U.S. Pat. No. 6,787,313, issued Sept. 7, 2004 (cited on PTO-892, attached to 
             this decision)                                                                                          





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