Ex Parte LOVE et al - Page 17


                Appeal No. 2006-2415                                                                               Page 17                     
                Application No. 09/410,336                                                                                                     

                         We also do not agree with Appellants’ argument (Appeal Brief, pages 18-21) that                                       
                the cited references fail to provide a sufficiently specific teaching, suggestion or                                           
                motivation to practice the claimed invention.  One of ordinary skill viewing the cited                                         
                references would have recognized that the claimed combination of steps would have                                              
                been desirable in a method of detecting cancer cells within the breast ductal network.                                         
                         Thus, one of ordinary skill detecting cancerous lesions according to Yoshimoto                                        
                would have recognized from Schmitt-Willich the advantage of a more stable detectable                                           
                agent, as well as the diagnostic advantage of using an antibody specific for breast                                            
                cancer tumors.  The skilled artisan also would have recognized that washing away non-                                          
                specifically bound detecting agent from the breast ductal network would result in less                                         
                background signal, thereby increasing assay specificity, much like the washing step in                                         
                Canto.  Lastly, Barsky would have informed the skilled artisan of the advantages of non-                                       
                percutaneous cannulation.  In our view, by looking only to the prior art cited by the                                          
                examiner, one of ordinary skill would have had incentive to practice the claimed                                               
                process.                                                                                                                       
                         Appellants’ additional arguments with respect to this rejection have been                                             
                adequately addressed above.                                                                                                    
                         Therefore, we conclude that a preponderance of the evidence supports the                                              
                examiner’s position that Yoshimoto, Schmitt-Willich, Canto and Barsky would have                                               
                rendered claim 34 prima facie obvious.  Claim 35 falls with claim 34.                                                          
                                                                 Summary                                                                       
                         We affirm the rejections of claims 33-39 under 35 U.S.C. § 103.                                                       







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