Ex Parte Totterman et al - Page 4

               Appeal 2006-2514                                                                             
               Application 10/233,562                                                                       
                            necrotic core biomarker (column 6, lines 19                                     
                            through 36).                                                                    
               Gilhuijs uses statistical segmentation in the analysis of a breast tumor (Col.               
               4, ll. 31 through 34).                                                                       
                      Although Gilhuijs describes a breast tumor, Kennedy takes a three-                    
               dimensional image of the brain to locate a biomarker (e.g., a brain lesion or                
               tumor, brain white matter and the shape of the tumor or lesion) (Col. 3, l. 25               
               through Col. 4, l. 9).  Kennedy derives at least one quantitative measurement                
               (i.e., volumetric measurements of tumor size) of the at least one biomarker                  
               (Col. 2, ll. 3 through 52), and stores the results of the measurement along                  
               with an identification of the biomarker (Col. 4, l. 63 through Col. 5, l. 18 and             
               Col. 9, ll. 15 through 35).  Kennedy uses motion tracking and estimation                     
               during the measurement of tumor expansion (Col. 4, ll. 3 through 9).  A                      
               histogram is used by Kennedy to model or display three-dimensional images                    
               taken over time of a region of interest (Col. 2, l. 56 through Col. 3, l. 6; Col.            
               5, l. 51 through Col. 6, l. 4).                                                              
                      Gilhuijs and Kennedy are applied together in the obviousness                          
               rejection of claims 1 to 8, 10 to 18 and 20 to 24.  Gilhuijs, Kennedy and                    
               Front are applied together in the obviousness rejection of claims 9 and 19.                  
                      As indicated supra, Appellants contend that the skilled artisan would                 
               not have found it obvious to combine the teachings of the references because                 
               they scan two different parts of the human body.                                             
                                          PRINCIPLES OF LAW                                                 
                      “In reviewing the [E]xaminer’s decision on appeal, the Board must                     
               necessarily weigh all of the evidence and argument.”  In re Oetiker, 977                     
               F.2d 1443, 1445, 24 USPQ2d 1443, 1444 (Fed. Cir. 1992).                                      

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