Ex Parte Tzipori et al - Page 16

                  Appeal  2006-2945                                                                                            
                  Application 10/041,958                                                                                       
                  effective in treating HUS.  Accordingly, we do not find Appellants’                                          
                  argument persuasive.                                                                                         

                  Williams:                                                                                                    
                  A12.  “It is not clear that Williams is available as prior art, even under 35                                
                  U.S.C. [§] 102(e), since it issued on an application filed March 13, 1997,                                   
                  well after [A]ppellants’ priority date of November 15, 1996” (Br. 17).                                       
                          “To fully demonstrate [that] the teachings of Williams are entitled to                               
                  the filing date of the CIP application, [the Examiner enclosed] page 9 of the                                
                  CIP Application, 08/410,058” with the Answer (Answer 9).  According to                                       
                  the Examiner “[t]his page demonstrates verbatim support of the text relied                                   
                  upon in the rejection” (id.).  While, Appellants address Williams in their                                   
                  Reply Brief, they do not refute the Examiner’s assertion that Williams is                                    
                  properly available as prior art (see, e.g., Reply Br. 6-7).  Accordingly, we do                              
                  not find this argument persuasive.                                                                           

                  A13.  “Williams is drawn to the use of avian antibodies elicited by                                          
                  immunization of birds with recombinant, preferably cross-linked toxin                                        
                  fragments. . . .  There is no teaching or even recognition that one cannot                                   
                  inject avian antibodies into humans . . .” (Br. 17-18, emphasis removed).                                    
                          Appellants’ argument is not consistent with the combination of                                       
                  evidence relied upon by the Examiner.  For example, Williams expressly                                       
                  states that the “antitoxins are useful in the treatment of humans and other                                  
                  animals intoxicated with at least one bacterial toxin” (Williams, abstract).                                 
                  Further, notwithstanding Williams’ express teaching of the treatment of                                      
                  humans, the combination of evidence relied upon by the Examiner teaches                                      

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