Appeal 2006-3083
Application 10/121,634
for sterilization, to control bleeding from a wound or during surgery, or to
cut off blood flow to a tumor” (Specification 1).
“The reactive monomers most commonly used for in situ
polymerization are alkyl-2-cyanoacrylates having one polymerizable
cyanoacrylate group per monomer, such as n-butyl-2-cyanoacrylate” (id. at
2). “However, the simple alkyl-2-cyanoacrylates have a number of
drawbacks. For example, they generate an undesirable amount of heat as
they rapidly polymerize. Also, the rapidly forming, adhesive polymers can
trap the injection catheters, making it difficult to safely remove the
instruments.” (Id.)
The Specification discloses that these drawbacks are overcome by
making occlusive compositions comprising a “monomer having multiple
cyanoacrylate reactive sites per molecule – a poly(2-cyanoacrylate)
monomer” (id. at 4: 15-16). “[I]t is believed that the advantages of the
poly(2-cyanoacrylate) monomer derive at least in part from its ability to
form cross-linked polymeric masses. As a result, even a relatively slow
polymerization rate can provide a rapid increase in viscosity, which is
necessary to form an occlusion in a high fluid flow environment.” (Id. at
12: 13-17.)
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Last modified: September 9, 2013