Ex Parte Langenhove et al - Page 11


               Appeal No. 2006-3202                                                                    Page 11                  
               Application No. 10/323,592                                                                                       

               through the vessel, the detection of plaque temperatures within the claimed range could                          
               be considered an inherent result5 of carrying out the Casscells’ method.  threshold                              
               temperature and how this difference is reflected in the claimed subject matter.                                  
                      2)   Is there other prior art which would have enabled temperature measurements                           
               of inflamed plaques to be have been made within the claimed range?                                               
                      If Casscells ‘261 would not have enabled temperature measurements to have                                 
               been made in the claimed range, the Examiner should determine whether WO                                         
               01/742163, which is cited on page 7, lines 14-15 of the instant application as describing                        
               a preferred temperature measuring device, is prior art to the instant application.  If so,                       
               the Examiner should consider whether there is adequate evidence to establish a prima                             
               facie case of obviousness over the combination of it and Casscells ‘261.                                         
                      Additionally, we note that WO 01/742163 is pending as U.S. Application No.                                
               10/169,523, which appears to have the same assignee as the instant application.  The                             
               cited references in 10/169,523, particularly the references applied in the pending                               
               rejections, may also be combinable with Casscells ‘262 to establish prima facie                                  
               obviousness of claims 30-33, or other pending claims in the instant application.                                 
                      3)  Is the instant application enabling under § 112, first paragraph, for diagnosing                      
               plaques at a temperature “above zero but not more than 0.14°C”?                                                  
                      In order to make a rejection under § 112, first paragraph, the examiner has the                           
               initial burden to establish a reasonable basis to question the enablement provided for                           



                                                                                                                                
               5 Because this reference is cited in the context of §103, we have not considered whether there is                
               sufficient evidence to establish inherent anticipation under § 102.                                              




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