Ex Parte Davis - Page 14


                  Appeal No. 2006-3204                                                             Page 14                      
                  Application No. 10/057,629                                                                                    

                  ibuprofen for aspirin or acetaminophen, in a formulation containing                                           
                  pseudoephedrine, would be considered nonobvious if the new composition did                                    
                  the same thing as the old ones but had fewer side-effects.  This is not the                                   
                  appropriate standard.  Cf. Richardson-Vicks, Inc. v. Upjohn Co., 122 F.3d 1476,                               
                  1483-84, 44 USPQ2d 1181, 1187 (Fed. Cir. 1997).                                                               
                          Finally, whether an invention satisfied a long-felt need, and what relevance                          
                  that has to obviousness, must be considered in light of the state of the art at the                           
                  time the invention was made:  that an invention satisfied a long-felt need has little                         
                  relevance to obviousness if the means for satisfying that need became available                               
                  in the art only recently.  See, e.g., Graham vs. John Deere Co., 383 U.S. 1, 36,                              
                  148 USPQ 459, 474 (1966) (“At the latest, those differences [between the                                      
                  claimed and prior art products] were rendered apparent in 1953 by the                                         
                  appearance of the Livingstone patent, and unsuccessful attempts to reach a                                    
                  solution to the problems confronting [the inventor] made before that time became                              
                  wholly irrelevant.”); In re Sabatino, 387 F.2d 981, 986, 156 USPQ 212, 216                                    
                  (CCPA 1968) (“[T]he evidentiary value of the many apparently unsuccessful                                     
                  attempts to [solve the problem addressed by the invention] appears to be well-                                
                  tempered by the fact that those attempts occurred before Rigsby, the most                                     
                  pertinent reference, became available to those in the art.”).                                                 
                          Therefore, any need that existed before ezetimibe was known to those                                  
                  skilled in the art is irrelevant to the question at hand – whether it would have                              
                  been obvious to use ezetimibe to treat sitosterolemia.                                                        






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