Appeal 2006-3252
Application 09/536,728
1 The term stress incontinence refers to a sudden loss of urine, which is
2 caused by incompetence of the bladder outlet during unobtrusive movement
3 of the bladder as a result of interabdominal increases in pressure due, inter
4 alia, to coughing, pressing, sneezing and heavy lifting. Publication, ¶ 0003.
5 Among the preferred compounds for Esser's purpose are imidazolines
6 of the general formula:
R4 R5 H
N
R3 N
N
7 R2 R1 H
8
9 Formula 1
10 wherein
11
12 R1, R2, R3, R4, and R5 denote, independently of one another:
13
14 [1] hydrogen, [2] C1-6-alkyl, preferably C1-4-alkyl, most
15 preferably methyl, [3] C3-6-cycloalkyl, preferably cyclopropyl, [4]
16 C1-6-alkoxy, [5] preferably C1-4-alkoxy, most preferably methoxy,
17 [6] halogen, preferably chlorine or bromine, [7] ―CF3, [8] ―OCF3 or
18 [9] ―NR6R7 wherein
19
20 R6 denotes [1] hydrogen, [2] C3-6-cycloalkyl, [3] C1-6-alkyl,
21 preferably C1-4-alkyl, most preferably methyl, or [4] C2-4-acyl, most
22 preferably acetyl,
23
24 R7 denotes [1] hydrogen, [2] C3-6-cycloalkyl, preferably
25 cyclopropyl, [3] C1-6-alkyl, preferably C1-4-alkyl, most preferably
26 methyl, or [4] C2-4-acyl, most preferably acetyl; or
8
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Last modified: September 9, 2013