Ex Parte Wisniewski et al - Page 2

                 Appeal 2006-3326                                                                                        
                 Application 09/881,909                                                                                  

                        a structure positioned in the container such that the structure segments                         
                 the container into a plurality of compartments wherein a distal end of the                              
                 structure is in close proximity to an interior surface of the container to allow                        
                 formation of a thermal transfer bridge, by said medium, wherein heat is                                 
                 transferred from said distal end of the structure through said thermal bridge                           
                 to said interior wall in response to said interior wall being actively cooled.                          

                        The Examiner relies upon the following references in the rejection of                            
                 the appealed claims:                                                                                    
                 Voorhees   US    983,466  Feb. 7, 1911                                                                  
                 Morrison   US 1,874,578  Aug. 30, 1932                                                                  
                 West    US 2,114,642  Apr. 19, 1938                                                                     
                 Finnegan   US 2,129,572  Sep. 6, 1938                                                                   
                 Brown   US 2,391,876  Jan. 1, 1946                                                                      
                 Gross    US 2,915,292  Dec. 1, 1959                                                                     
                 Burroughs   US 3,318,105  May 9, 1967                                                                   
                 Euwema   US 3,550,393  Dec. 29, 1970                                                                    
                 Nakao (as translated) JP 57-58087   Apr. 7, 1982                                                        
                 Kalhori, "Studies on Heat Transfer From a Vertical Cylinder, With or                                    
                 Without Fins, Embedded in a Solid Phase Change Medium," Transactions                                    
                 of the ASME, Journal of Heat Transfer, Vol. 107, 44-51 (Feb. 1985).                                     
                 Nagashio (as translated)   JP 3-43390   Feb. 25, 1991                                                   
                 Wisniewski, "Large-Scale Freezing and Thawing of Biopharmaceutical                                      
                 Drug Product," Proceedings of the International Congress, Advanced                                      
                 Technologies For Manufacturing of Aseptic & Terminally Sterilized                                       
                 Pharmaceuticals & Biopharmaceuticals, 132-139 (Feb. 1992).                                              
                 Koerber   JP 06064094 A  Mar. 8, 1994                                                                   
                 Cothern   US 5,535,598  Jul. 16, 1996                                                                   
                        Appellants' claimed invention is directed to a thermal transfer system                           
                 comprising a container that receives a medium, a structure within the                                   


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