Ex Parte Shekunov et al - Page 4



                 Appeal 2007-0414                                                                                       
                 Application 10/691,113                                                                                 

                 through which the liquid flows.(para. [0041]).  Hence, we find no merit in                             
                 Appellants’ argument that “[w]hile the batch flash mixer of Johnson et al.                             
                 does contain a rotating mechanical agitator or rotor disposed in a mixing                              
                 vessel, the non-process solvent does not flow through the mixing vessel as                             
                 required by the claimed method” (principal Br. 6, penultimate para.).                                  
                        We are also not persuaded by Appellants’ argument that paragraph                                
                 [0063] of Johnson only relates to using supercritical fluid extraction for post                        
                 treatment processes (see principal Br. 7).  Rather, Johnson clearly teaches                            
                 that although supercritical fluid extraction typically occurs after nanoparticle                       
                 formation, it can also be employed “during the nanoparticle formation                                  
                 process” (para. [0063], last sentence).                                                                
                        Appellants also maintain that Johnson does not disclose the claim 9                             
                 recitation that the first and second solution ports are coaxial.  However, we                          
                 concur with the Examiner that paragraph 0045 of Johnson teaches that the                               
                 mixer can include multiple inlet tubes for introducing a plurality of streams                          
                 and that, in one embodiment, “the fluid streams can be directed towards each                           
                 other to substantially cause them to collide and mix.”  In our view, this                              
                 disclosure fairly describes the claimed coaxial ports.  As for the claim 14                            
                 recitation that the process solvent could be an emulsion, Johnson fairly                               
                 describes as much by disclosing the addition of emulsifiers to the process                             
                 solvent (para. [0064], l. 7).                                                                          
                        Although Appellants agree that Johnson discloses “forming coated                                
                 additive target molecules that could have a core-shell configuration,                                  

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