Ex Parte Murphy et al - Page 7




              Appeal No. 2007-0534                                                                                       
              Application No. 10/463,016                                                                                 
              Specification, pages 9-10 and 12.                                                                          
                     Similarly, the prior art cited in the present case in both instances uses broad                     
              terminology to describe protein-protein interactions.  See, e.g., Hamilton, claim 1; Silver                
              claim 1.                                                                                                   
                     In view of the existing knowledge in the particular field, the extent and content of                
              the prior art cited in this case, the maturity of the science or technology of protein-                    
              protein interactions, and the predictability of the aspect at issue, in our view the claimed               
              invention is adequately described in the specification when read in view of the eyes of                    
              one of ordinary skill in the art.                                                                          
                     The rejection of the claims for lack of written description is reversed.                            


             35 U.S.C. § 103(a)                                                                                          
                     Claims 1, 2, 5, 7-11, 15, 16, and 27-31 stand rejected under 35 U.S.C. § 103(a)                     
              over Silver.                                                                                               
                     According to the examiner, Silver's method involves using DNA encoding a                            
              protein of interest tagged with one member of a fluorescent protein pair and DNA                           
              sequences encoding a plurality of proteins to be screened, wherein the screening                           
              proteins are tagged to the other member of the fluorescent pair.   Answer, page 6.                         
              When the proteins are located physically within an appropriate distance of one another                     
              fluorescence resonance energy transfer (FRET) occurs between the fluorescent protein                       
              pair.  Abstract, Answer, page 6.                                                                           

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