Ex Parte Frey et al - Page 6

              Appeal No. 2007-0542                                                                 
              Application No. 10/301,185                                                           

              trigeminal nerves in the nasal cavity may be an inherent mechanism (in               
              addition to the absorption along the olfactory neurons) responsible for              
              transport into the brain, the Examiner has not provided evidence that this           
              mechanism would have been recognized by the person of ordinary skill in              
              the art.  “That which may be inherent is not necessarily known. Obviousness          
              cannot be predicated on what is unknown.” In re Spormann, 363 F.2d 444,              
              448, 150 USPQ 449, 452 (CCPA 1966).  See also Rijckaert, at 9 F.3d 1534,             
              28 USPQ2d 1957.  The Examiner’s burden is not discharged by the mere                 
              fact that trigeminal nerves are present in the nasal cavity.                         
                                     CONCLUSION OF LAW                                             
                    The Examiner has not shown that Frey provides adequate motivation              
              to have made it obvious under 35 U.S.C. § 103 to administer NGF or FGF to            
              a skin region outside the nasal cavity, but innervated by the trigeminal nerve.      
              We reverse the Examiner’s rejection of claims 45-48, 50, 52, and 53.                 

                                           REVERSED                                                

                                Toni R. Scheiner   )                                               
                                Administrative Patent Judge )                                      
                                                             )                                     
                                                             )                                     
                                                             ) BOARD OF PATENT                     
                                Lora M. Green   )                                                  
                                Administrative Patent Judge )   APPEALS AND                        
                                                             )                                     
                                                             ) INTERFERENCES                       
                                                             )                                     
                                Richard M. Lebovitz  )                                             
                                Administrative Patent Judge )                                      


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