Appeal 2007-1070
Application 09/467,901
(Frank, col. 2, ll. 17-25.)
Johnson
14. Johnson teaches that CD23 is a cellular receptor for IgE (Answer 6).
Obviousness over Johansen and Frank in view of Johnson
15. The Examiner contends:
It would have been obvious to one of ordinary skill in the art to
use the IgE receptors of Johnson et al. and Frank et al. to
measure IgE according to the method of Johansen et al. since
both of these receptors, CD23 and [FcεR], are specific to IgE
antibody and because [FcεR] and CD23 can bind to IgE with
less isotype cross-reactivity and more sensitivity than anti-IgE
binding antibodies. (See Frank et al. Col. 1, lines 19-34).
(Answer 6.)
Arnold
16. Arnold teaches
in the background section that a typical sandwich assay
involve[s] incubating an immobilized antibody (IgE receptor)
with a test medium (sample). Antigens, if in the medium, will
bind to the antibody. After incubation, unbound antigen is
removed in a separation step. After a second, or simultaneous
incubation with a solution of labeled antibody, the bound
antigen becomes sandwiched between the immobilized
antibody and the labeled antibody. After a second separation
step, the amount of labeled antibody can be determined as a
measure of the antigen in the medium. (see col. 1, lines 55-66).
(Answer 7.)
Obviousness over Arnold
17. The Examiner states that it would have been obvious to a person of
ordinary skill in the art to have utilized first and second separation steps as
taught by Arnold for their known advantages (Answer 7).
8
Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Next
Last modified: September 9, 2013