Ex parte MIZUSAWA et al. - Page 9


                 Appeal No.  1996-0906                                                                                   
                 Application No.  08/110,341                                                                             


                 The Butler in view of Thom and Matsuo series:                                                           
                        The examiner reasons (Answer, bridging paragraph, pages 8-9):                                    
                        It would have been obvious to use lipase from Pseudomonas as the                                 
                        hydrolytic enzyme immobilized by Butler on cloth to produce a self-                              
                        cleaning cloth to obtain the function of the lipase when used in                                 
                        detergent compositions and pre-soak liquids as disclosed by Thom et                              
                        al, i. e. to obtain the function of the lipase to hydrolyze oil and aid in its                   
                        removal from cloth.  The use of lipase as the immobilized hydrolytic                             
                        enzyme of Butler would have been particularly obvious when                                       
                        producing a self-cleaning butcher’s apron since a butcher’s apron is                             
                        well known to come into contact with oil and fat contained by meat                               
                        being butchered.…  [I]t would have been obvious that enzymes could                               
                        be adsorbed directly on the cloth without derivatizing in view of                                
                        Matsuo et al disclosing adsorbing lipase directly to different carriers                          
                        including a cellulose carrier (col 5, lines 45-50).                                              
                        Appellants argue (Reply Brief, pages 6-7) referencing column 55, lines                           

                 20-23, that “Butler teaches away from combining such a ‘self-cleaning’ cloth                            
                 or carrier with a detergent composition, such as that of Thom et al.”  In view                          
                 of the teachings of Butler, column 5, lines 20-23, appellant urges (Reply Brief,                        
                 page 7) that “to somehow combine such a derivatized cloth [of Butler] with an                           
                 enzymatic detergent composition with ‘improved overall detergency’ such as                              
                 Thom … would surely completely remove the protein from the cloth and thus,                              
                 defeat the very goal of Butler.”                                                                        





                                                                                                                         
                 5 We note appellants’ reference to “Butler, column 6, lines 20-23” (Reply Brief, page                   
                 7).  However, the quoted section of Butler is from column 5, lines 20-23.  The correct                  
                 reference page is recited herein.                                                                       

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