Ex parte ROBERT R. BARTLETT - Page 8




                Appeal No. 94-2990                                                                                                            
                Application 07/932,577                                                                                                        


                first injection of the donor cells”.  See Bartlett, column 2,                                                                 
                lines 63 through 65.  Bartlett further discloses an experimental                                                              
                protocol for treatment “[f]rom day 17 onwards” in column 3, lines                                                             
                4 through 30.  Manifestly, the Bartlett reference, considered                                                                 
                alone or in conjunction with the remaining references relied on                                                               
                by the examiner, is insufficient to support a conclusion of                                                                   
                obviousness of method claims containing the limitation                                                                        
                “hyperacute”.  As discussed supra, that limitation is critical                                                                
                and restricts the timing of administration of appellant’s                                                                     
                pharmaceutical composition in method claims 11 through 15, 22 and                                                             
                23.                                                                                                                           
                         We next consider claims 16 through 21, drawn to a method of                                                          
                treating rejection reactions of an organ recipient to a                                                                       
                transplanted organ from a different species.2                                                                                 
                         Again, we find that Bartlett constitutes the closest prior                                                           
                art.  Having carefully reviewed the Bartlett patent in its                                                                    


                entirety, we find that this patent is restricted to allogeneic                                                                
                transplantation.  This follows because:                                                                                       


                         2   As explained in the Auchincloss reference, relied on by the examiner,                                            
                xenogeneic transplantation is the transplantation of organs or tissues from a                                                 
                member of one species to that of another. Allogeneic transplantation is the                                                   
                transplantation of organs or tissues between members of the same species.                                                     
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