Appeal No. 94-1696
Application 07/811,129
de Fougerolles et al. (de Fougerolles), “Characterization of
ICAM-2 and Evidence for a Third Counter-Receptor for LFA-1," J.
Exp. Med., vol. 174, pp. 253-267 (1991).
Dustin et al. (Dustin), “Induction by IL 1 and Interferon-(:
Tissue Distribution, Biochemistry, and Function of a Natural
Adherence Molecule (ICAM-1),” The Journal of Immunology, vol.
137, pp. 245-254 (1986).
Makgoba et al. (Makgoba), “ICAM-1 a Ligand for LFA-1-Dependent
Adhesion of B, T and Myeloid Cells,” Nature, vol. 331, pp. 86-88
(1988).
Nortamo et al. (Nortamo), “A Monoclonal Antibody to the Human
Leukocyte Adhesion Molecule Intercellular Adhesion Molecule-2,”
The Journal of Immunology, vol. 146, pp. 2530-2535 (1991).
Claims 1 through 17 stand rejected under 35 U.S.C. § 103 as
being unpatentable over Springer in view of Zettlmeissl.
Having carefully considered the entire record which
includes, inter alia, the specification, the appellants’ main
Brief (Paper No. 12) and Reply Brief (Paper No. 15), the
examiner’s Answer (Paper No. 13) and Supplemental Answer (Paper
No. 16), we find ourselves in substantial agreement with the
appellants’ position. Accordingly, we reverse the rejection.
Our reasons follow.
Background
The appellants’ invention is directed to soluble fusion
proteins which comprise a first region capable of binding to the
3
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