Ex parte ARUFFO et al. - Page 5

          Appeal No. 94-1696                                                          
          Application 07/811,129                                                      

          and its critical role in an immune response.  Springer discloses,           
          inter alia, that three T cell receptor molecules, LFA-1                     
          (CD11a/CD18), LFA-2 (CD2) and LFA-3, “account for the antigen-              
          independent adhesion that is induced by the prolonged antigenic             
          stimulation of T cells in vitro and presumably help localize                
          activated T cells to sites of antigen accumulation in the lymph             
          nodes in vivo.” [Footnotes omitted.]   Springer, p. 426, col. 1,            
          lines 7-11.  Springer further discloses that the counter receptor           
          on the target cell for LFA-1 is ICAM-1 or ICAM-2 (intercellular             
          cell molecule).  Id., sentence bridging cols. 1 and 2.  Springer            
          still further discloses that ICAM-1 and ICAM-2 are members of an            
          immunoglobulin superfamily; structurally, ICAM-2 has two                    
          immunoglobulin-like domains and ICAM-1 has five.                            
               Zettlmeissl discloses the construction of a soluble fusion             
          protein which comprises a first region encoding the T cell                  
          receptor CD4 and a second region derived from different parts of            
          human IgG  or IgM heavy-chain constant regions.  According to               
          Zettlmeissl, such fusion proteins are promising therapeutic                 
          agents for HIV (human immunodeficiency virus) infections.                   


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