Appeal No. 94-1696
Application 07/811,129
and its critical role in an immune response. Springer discloses,
inter alia, that three T cell receptor molecules, LFA-1
(CD11a/CD18), LFA-2 (CD2) and LFA-3, “account for the antigen-
independent adhesion that is induced by the prolonged antigenic
stimulation of T cells in vitro and presumably help localize
activated T cells to sites of antigen accumulation in the lymph
nodes in vivo.” [Footnotes omitted.] Springer, p. 426, col. 1,
lines 7-11. Springer further discloses that the counter receptor
on the target cell for LFA-1 is ICAM-1 or ICAM-2 (intercellular
cell molecule). Id., sentence bridging cols. 1 and 2. Springer
still further discloses that ICAM-1 and ICAM-2 are members of an
immunoglobulin superfamily; structurally, ICAM-2 has two
immunoglobulin-like domains and ICAM-1 has five.
Zettlmeissl discloses the construction of a soluble fusion
protein which comprises a first region encoding the T cell
receptor CD4 and a second region derived from different parts of
human IgG or IgM heavy-chain constant regions. According to
1
Zettlmeissl, such fusion proteins are promising therapeutic
agents for HIV (human immunodeficiency virus) infections.
5
Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Next
Last modified: November 3, 2007