Ex parte KLOKKERS-BETHKE et al. - Page 2




          Appeal No. 94-3564                                                          
          Application 07/890,314                                                      



                                REPRESENTATIVE CLAIM                                  

               Claim 16, which is illustrative of the subject matter on               
          appeal, reads as follows:                                                   

               16.  A medicinal product for the buccal administration of              
          nitroglycerin to a patient in need of nitroglycerin therapy                 
          comprising:                                                                 
                    a container having a pump spray means for dispensing a            
          spray dosage of a composition in the container into the buccal              
          area of a patient’s mouth;                                                  
                    the composition being a hydrophilic aqueous pump spray            
          composition comprising 0.15 to 0.50 weight/% of nitroglycerin,              
          24.50 to 24.85 weight/% of ethanol, 32.00 weight/% of 1,2-                  
          propyleneglycol and 43.00 weight/% of purified water and having a           
          pH of 3 to 6; and                                                           
                    the composition and the container containing no                   
          propellant.                                                                 

                                   THE REFERENCES                                     

               In rejecting the appealed claims on prior art grounds, the             
          examiner relies on three references.  The first cited reference             
          is European Patent Application 310,910 published April 12, 1989.            
          We shall hereinafter refer to the European Patent Application by            
          the name of its lead inventor, Aouda.  The second reference is              
          U.S. Patent No. 3,155,574 issued November 3, 1964, to Silson et             
          al. (Silson).                                                               

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