Ex parte MATHIOWITZ - Page 13




          Appeal No. 95-2876                                                          
          Application 07/906,403                                                      


               Claim 20 through 23 are rejected under 35 U.S.C.  102 as              
          anticipated by, or in the alternative under 35 U.S.C.  103 as              
          being obvious over the disclosure of Beck.                                  
               Beck describes multi-layered microparticles which are                  
          useful for carrying pharmaceutical agents.  See column 3,                   
          lines 55-68 in conjunction with Figures 2 through 5.  Figure 5              
          specifically shows a spherical microparticle formed of a core               
          of one particular pharmaceutical agent surrounded by a shell                
          of matrix material containing a second type of pharmaceutical               
          agent.  See column 3, lines 65-68 in conjunction with column                
          10, lines 21-24.  The core of the spherical microparticle of                
          Figure 5 is prepared (column 9, lines 54-57) such that                      
               [t]he antigen or antibody alone can constitute                         
               the core of the microparticles or the antibody or                      
               antigen can dispersed in matrix material to form a                     
               core 11.                                                               
          Beck then goes on to state (see the paragraph bridging columns              
          9 and 10):                                                                  
               Moreover, while multi-layered microparticles                           
               such as the types shown in FIGS. 2, 4 and 5 are                        
               normally formed of a single type of matrix material,                   
               it is possible, if not desirable under some                            
               circumstances, to formulate contiguous layers of the                   
               microparticles from different matrix materials.                        
               Still further it is possible that under some                           
               circumstances, it may be desirable to deliver more                     
               than one antibody or antigen to the internal                           
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