Appeal No. 94-4129
Application 07/953,439
effects. However, galanthamine has additional special effects
due to its lower toxicity (Specification, pages 4-5, bridging
paragraph).
G. Galanthamine is ten times less potent as an
anesthetic than neostigmine (Wislicki, page 965, column 2,
last paragraph).
H. The evidence of record does not establish the
relative activities of galanthamine to physostigmine for any
purpose, of galanthamine to neostigmine for uses other than
anesthesia, and of physostigmine to neostigmine for any
utility.
I. In 1994, Hille II teaches that he considered the
discovery that galanthamine could be administered
transdermally remarkable “since the structure of galanthamine
is very similar to that of the opiates. Opiates are
considered to be a substance class which only insufficiently
penetrates human skin” (Hille II, column 1, lines 52-55).
J. The evidence of record does not establish whether or
not or the reasons why persons having ordinary skill in the
art might reasonably expect a known active agent to be
effectively administrable transdermally.
3. Discussion
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