Ex parte TAKANOHASHI et al. - Page 3




          Appeal No. 95-0334                                                          
          Application 08/002,513                                                      

          in yields comparable to prior art methods wherein diacetone-2-              
          keto-L-gulonic acid (DAGA) is used as the starting material.                
               Appealed claims 1 and 3-6 stand rejected under 35 U.S.C.               
          § 103 as being unpatentable over Fujiwara in view of Bassford               
          and Japanese '217.                                                          
               Upon thorough review of the opposing arguments presented               
          by appellants and the examiner, we concur with appellants that              
          the examiner has failed to establish a prima facie case of                  
          obviousness for the claimed subject matter.  Accordingly, we                
          will not sustain the examiner's rejection.                                  
               The examiner recognizes that Fujiwara discloses making                 
          L-ascorbic acid from either DAGA or GA, but without an                      
          aliphatic ketone being present in the starting reaction                     
          medium.  To remedy this deficiency in Fujiwara, the examiner                
          relies upon the disclosures of Bassford and Japanese '217.                  
          Bassford teaches that when L-ascorbic acid is prepared from                 
          DAGA, a ketone, such as acetone, is liberated and dissolves in              
          the solvent layer, thereby facilitating its removal from the                
          reaction medium.  Japanese '217 incorporates acetone in a                   
          reaction medium comprising DAGA to dissolve intermediate ester              
          compounds.  Based on the disclosures of Bassford and Japanese               
          '217, the examiner concludes that it would have been obvious                

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