Ex parte BOUFFARD et al. - Page 9




          Appeal No. 95-0976                                                          
          Application No. 07/936,558                                                  


                                     BACKGROUND                                       
               Claims 1-12 are drawn to compounds which are derivatives               
          of known cyclohexapeptidyl compounds.  These compounds are                  
          known in the art as echinocandins.  Claims 13 and 14 are drawn              
          to antibiotic compositions comprising the compounds of claim                
          1.                                                                          
               The compounds that were starting materials for the                     
          production of the claimed compounds are echinocandin                        
          hexapeptidyl compounds extracted from microbial fermentates.                
          These parent compounds and their antibiotic activity were                   
          known prior to the filing date of this application.                         
                                     DISCUSSION                                       
                         Rejection based on 35 U.S.C. § 112                           
               Claim 1 stands rejected under 35 U.S.C. § 112, first                   
          paragraph, as having been based on a non-enabling disclosure.               
               Although phrased various ways the position of the                      
          examiner is that the single in vivo example of the claimed                  
          antibiotic activity is inadequate to provide the necessary                  
          guidance to one of skill in the art to practice the invention               
          across the scope of the claim.  The claims at issue encompass               


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