Ex parte CACECI et al. - Page 14




          Appeal No. 95-2041                                                          
          Application 07/814,220                                                      


          that we have not decided the merits of the issues raised by                 
          the examiner therein.  If prosecution is continued on this                  
          subject matter, and claims are presented which meet the                     
          requirements of 35 U.S.C. § 112, second paragraph, the                      
          examiner should revisit these issues.                                       
               Claims 17-20 stand rejected under 35 U.S.C. § 103 over                 
          Gourlie and Peters in view of Chakrabartty, Houghten and Scott              
          and further in view of any one of Williams, Ferrari, Shen,                  
          Doel, Kempe or Willson.                                                     
               We reverse this rejection.  A prima facie case of                      
          obviousness has not been presented by the Examiner.                         
               The combined prior art teachings do not provide a                      
          reasonable basis for increasing the number of 11 amino acid                 
          sequence repeats in the antifreeze polypeptide of winter                    
          flounder to establish that the claimed genes and transformed                
          hosts which produce such polypeptides would have been obvious               
          to a person having ordinary skill in the art at the time of                 
          the invention.  The reasoning presented in the rejection is                 
          stated in the Examiner’s Answer, beginning on the last line of              
          page 13 and continuing through lines 1-14, of page 14, as:                  


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