Ex parte CACECI et al. - Page 7




          Appeal No. 95-2041                                                           
          Application 07/814,220                                                       


          second complete paragraph.  Thus, claims 17-20 are not                       
          presently rejected under 35 U.S.C. § 112, first paragraph.                   


                   New Ground of Rejection Under 37 CFR § 1.196(b)                     
               Claims 6, 11, 21 and 32-47 are rejected under 35 U.S.C. §               
          112, second paragraph, as being indefinite for failing to                    
          particularly point out and distinctly claim the subject matter               
          which applicants regard as their invention.                                  
          1."modeled after"                                                            
               Claims 6, 11 and 32-47 recite, either expressly or via                  
          dependence on a claim that recites, a DNA sequence "coding for               
          an antifreeze polypeptide modeled after the antifreeze                       
          polypeptide found in winter flounder."  The metes and bounds                 
          of this language are not apparent, nor is there a specific                   
          definition in the specification that would provide a                         
          structural and/or functional limitation of the claimed DNA                   
          compounds.  Does the winter flounder possess more than one                   
          gene which encodes a protein which has an activity such that                 
          it can be classified as an "antifreeze polypeptide?"  How                    
          close to which protein produced by a winter flounder must a                  
          compound be in order to be considered as "modeled after" the                 
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