Appeal No. 95-2041
Application 07/814,220
a sequence of nucleotides coding for a protein which has an
amino acid sequence defined by blocks 1-6 of Figure 4.
The references relied upon by the examiner are:
Houghten 4,886,663 Dec. 12, 1989
Gourlie et al. (Gourlie), "Winter Flounder Antifreeze Pro-
teins: A Multigene Family," J. Biol. Chem., Vol. 259, No. 23,
pages 14960-14965 (1984).
Peters et al. (Peters), "Biosynthesis of Winter Flounder
Antifreeze Proprotein in E. coli," Protein Eng., Vol. 3, pages
145-151 (1989).
Scott et al. (Scott), "Structural Variations in the Alanine-
Rich Antifreeze Proteins of the Pleuronectinae," Eur. J.
Biochem., Vol. 168, pages 629-633 (1987).
Chakrabartty et al., (Chakrabartty), "Structure-Function
Relationship In A Winter Flounder Antifreeze Polypeptide,"
J. Biol. Chem., Vol. 265, pages 11313-11316 (1989).
Williams et al. (Williams), WO 88/05082, July 14, 1988.
Ferrari et al. (Ferrari), WO 88/03533, May 19, 1988.
Shen, "Multiple Joined Genes Prevent Product Degradation in
Escherichia coli," Proc. Natl. Acad. Sci., Vol. 81, pages
4627-4631 (August 1984).
Doel et al. (Doel), "The Expression in E. coli of Synthetic
Repeating Polymeric Genes Coding For Poly(L-Aspartyl-L-Phenyl-
alanine)," Nucl. Acids Res., Vol. 8, No. 20, pages 4575-4592
(September 1980).
Kempe et al. (Kempe), "Multiple-Copy Genes: Production and
Modification of Monomeric Peptides From Large Multimeric
Fusion Proteins", Gene, Vol. 39, pages 239-245 (1985).
3
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